Anesthesia Pharmacology in Pregnancy

Pregnancy induces significant changes in the pharmacokinetics of anesthetic drugs, necessitating a comprehensive understanding of these alterations for safe and effective obstetric anesthesia. These changes influence the absorption, distribution, metabolism, and elimination of anesthetic agents, impacting both maternal and fetal outcomes. 1. Absorption and Uptake During pregnancy, alterations in the gastrointestinal tract and cardiovascular system … Read more

Biomarkers in Anesthesia

Introduction to Biomarkers Characteristics of an Ideal Biomarker Characteristic Description High sensitivity with organ specificity Accurate detection of organ-related changes. Immediate release with tissue injury Rapid response to tissue damage. Release proportional to insult The extent of release correlates with the injury. Long half-life for predictiveness Sustained presence for predictive purposes. Rapid decrease in concentration … Read more

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