Precurarization in Succinylcholine: Mechanism, Procedure, and Doses
Precurarization is a technique used in anesthesia to reduce the potential adverse effects of succinylcholine. It is achieved by using a non-depolarizing neuromuscular blocking agent (NDNMB) to partially block nicotinic acetylcholine receptors (nAChRs) at the motor end plate. This partial blockade competes with acetylcholine (ACh) for binding to nAChRs, reducing the risk of succinylcholine-induced fasciculations … Read more