Inhaled general anesthetics play a crucial role in balanced anesthesia, with haemodynamic stability and early recovery being essential aspects of an effective anesthetic technique. Desflurane and sevoflurane are two recently developed inhaled anesthetics widely used for maintaining anesthesia. This study aims to observe and compare the haemodynamic effects and early recovery profiles of desflurane and sevoflurane in patients undergoing modified radical mastectomy under general anesthesia.
A prospective observational study was conducted on 50 patients, classified as ASA grades 2 and 3, who underwent modified radical mastectomy at the Department of Oncosurgery, Lakeshore Hospital, between September 2017 and February 2018. The first 25 consecutive patients meeting the inclusion criteria received desflurane (Group D), while the next 25 consecutive patients received sevoflurane (Group S). Anesthesia was induced using a standard sequence, and patients received either desflurane 4% or sevoflurane 2% for maintenance of anesthesia, guided by Bispectral index targeting values between 40 and 60. Haemodynamic parameters were recorded during induction, intubation, and at specific time intervals throughout the 2-hour maintenance phase. At the end of surgery, the inhaled anesthetic agent was discontinued, neuromuscular blockade was reversed, and the time taken for the patient to respond to verbal commands was measured as an indicator of early recovery. Adverse events during the procedure were also recorded. Statistical analysis involved independent t-tests, Mann-Whitney tests for quantitative variables, and Pearson Chi-square tests for categorical variables, with a significance level of p < 0.05.
The study compared the haemodynamic effects and early recovery profiles of desflurane and sevoflurane in patients undergoing modified radical mastectomy. The data collected from the 50 patients were analyzed to evaluate the differences in haemodynamic stability and recovery between the two anesthetic agents.
The results of this study will provide valuable insights into the comparative effects of desflurane and sevoflurane on haemodynamic stability and early recovery in patients undergoing modified radical mastectomy. Such knowledge may assist anaesthesiologists in selecting the most suitable anesthetic agent for this specific surgical procedure, thereby improving patient outcomes and overall surgical care.